青山学院大学 理工学部 化学・生命科学科 田邉一仁研究室 生体分析化学研究室

研究業績

田邉研究室優秀講演賞受賞者

  1. 令和元年度冬　M2　板谷亮汰　M1　本橋優人　B4　岸和哉
  2. 令和二年度夏　優秀講演賞　M2　本橋優人　M1　渡邉洸　B4　西田光輝　水谷美優　準優秀講演賞　M2 蒔苗宏紀　（B4は同点のため1位が2名）
  3. 令和二年度冬　優秀講演賞　M2　蒔苗宏紀　M1　盛谷周平　B4　山田梨紗　準優秀講演賞　M2 本橋優人　B4　西田光輝 　　　　　
  4. 令和三年度夏　優秀講演賞　M2　渡邉洸　M1　日高綾太　B4　前原大悟　準優秀講演賞　M1 杉本周平　西田光輝　B4　岡大陸　（M1は同点のため2位が2名） 　　　　　
  5. 令和三年度冬　優秀講演賞　M2　盛谷周平　M1　山田梨紗　B4　根岸賢輔　前原大悟　準優秀講演賞　M1 日高綾太　（B4は同点のため1位が2名）
  6. 令和四年度夏　優秀講演賞　M2　山田梨紗　B4　塚目莉加　準優秀講演賞　M2　西田光輝　B4　中島彩希　（M2とM1の両学年を含めて大学院生の賞を審査）
  7. 令和四年度冬　優秀講演賞　M2　日高綾太　B4　塚目莉加　準優秀講演賞　M2　山田梨紗　M1　前原大悟　B4 中島彩希　（M2とM1の両学年を含めて大学院生の賞を審査 同点のため2位が2名）
  8. 令和五年度夏　優秀講演賞　M2　前原大悟　B4　望月大輔　準優秀講演賞　M1　原田紗衣　B4　田村洸樹　（M2とM1の両学年を含めて大学院生の賞を審査）
  9. 令和五年度冬　優秀講演賞　M2　前原大悟　B4　田村洸樹　準優秀講演賞　M1　塚目莉加　B4　鈴木我空　（M2とM1の両学年を含めて大学院生の賞を審査）

原著論文

  1. Chiral amino acid recognition by a porphyrin-based artificial receptor, Kuroda, Y.; Kato, Y.; Higashioji T.; Hasegawa, J.; Kawanami, S.; Takahashi, M.; Shiraishi, N.; Tanabe, K.; Ogoshi H. J. Am. Chem. Soc. 1995, 117, 10950–10958.
  2. α-Diazoketones as photochemical DNA cleavers: A mimic for the radical generating system of neocartinostatin chromophore, Nakatani, K.; Maekawa, S.; Tanabe, K.; Saito, I. J. Am. Chem. Soc. 1995, 117, 10635–10644.
  3. Novel synthesis of bifurans via furan-forming photocyclization of α-diketones conjugated with ene-yne, Nakatani, K.; Tanabe, K.; Saito, I. Tetrahedron Lett. 1997, 38, 1207-1210.
  4. Tandem cyclization involving carbene as an intermediate: Photochemical reactions of substituted 1,2-diketones conjugated with ene-yne, Nakatani, K.; Adachi, K.; Tanabe, K.; Saito, I. J. Am. Chem. Soc. 1999, 121, 8221–8228.
  5. Site selective formation of thymine glycol-containing oligodeoxynucleotides by oxidation with osmium tetroxide and bipyridine-tethered oligonucleotide, Nakatani, K.; Hagihara, S.; Sando S.; Miyazaki H.; Tanabe, K.; Saito, I. J. Am. Chem. Soc. 2000, 122, 6309–6310.
  6. Synthesis and properties of peptide nucleic acids containing psoralen unit, Okamoto, A.; Tanabe, K.; Saito, I. Org. Lett. 2001, 3, 925–927.
  7. Modulation of remote DNA oxidation by hybridization with peptide nucleic acids (PNA), Okamoto, A.; Tanabe, K.; Dohno, C.; Saito, I. Bioorg. Med. Chem. 2002, 10, 713­–718.
  8. Site-specific discrimination between cytosine and 5-methylcytosine in duplex DNA using peptide nucleic acids (PNA), Okamoto, A.; Tanabe, K.; Saito, I. J. Am. Chem. Soc. 2002, 124, 10262­–10263.
  9. P-loop catalytically assisting the enzymatic cleavage of single-stranded DNA, Okamoto, A.; Tanabe, K.; Saito, I. Bioorg. Med. Chem. 2003, 11, 3747–3751.
  10. Phototriggered drug release from functionalized oligonucleotides by a molecular beacon strategy, Okamoto, A.; Tanabe, K.; Inasaki, T.; Saito, I. Angew. Chem. Int. Ed. 2003, 42, 2502–2504.
  11. One-electron reduction characteristics of N(3)-substituted 5-fluorodeoxyuridines synthesized as radiation-activated prodrugs, Tanabe, K.; Mimasu, Y.; Eto, A.; Tachi, Y.; Sakakibara, S.; Mori, M.; Hatta, H.; Nishimoto, S. Bioorg. Med. Chem. 2003, 11, 4551–4556.
  12. Photo-induced DNA cleavage reaction characteristics of propargylic sulfones possessing anthraquinone chromophore, Haruna, K.; Tanabe, K.; Ishii, A.; Dai, W. –M.; Hatta, H.; Nishimoto, S. Bioorg. Med. Chem. 2003, 11, 5311–5316.
  13. In vitro and in vivo evaluation of novel antitumor prodrugs of 5-fluoro-2’-deoxyuridine activated by hypoxic irradiation, Shibamoto, Y.; Tachi Y.; Tanabe, K.; Hatta, H.; Nishimoto, S. Int. J. Radiat. Oncol. Biol. Phys. 2004, 58, 397–402.
  14. Propargylic sulfones possessing a 2-nitroimidazole function: novel hypoxic-cell radiosensitizers with intracellular non-protein thiol depletion ability, Tanabe, K.; Kojima, R.; Hatta, H.; Nishimoto, S. Bioorg. Med. Chem. Lett. 2004, 14, 2633–2635.
  15. Cleavage at 5-methylcytosine in DNA by photosensitized oxidation with 2-methyl-1,4-naphthoquinone tethered oligodeoxynucleotides, Yamada, H.; Tanabe, K.; Nishimoto, S. Bioorg. Med. Chem. Lett. 2005, 15, 665–668.
  16. Hypoxia-selective activation of 5-fluorodeoxyuridine prodrug possessing indolequinone structure: radiolytic reduction and cytotoxicity characteristics, Tanabe, K.; Makimura, Y.; Tachi, Y.; Imagawa-Sato, A.; Nishimoto, S. Bioorg. Med. Chem. Lett. 2005, 15, 2321–2324.
  17. Bioreduction activated prodrugs of camptothecin: molecular design, synthesis, activation mechanism and hypoxia selective cytotoxicity, Zhang, Z.; Tanabe, K.; Hatta, H.; Nishimoto, S. Org. Biomol. Chem. 2005, 3, 1905–1910.
  18. A new class of 5-fluoro-2’-deoxyuridine prodrugs conjugated with a tumor-homing cyclic peptide CNGRC by ester linkers: synthesis, reactivity, and tumor-cell-selective cytotoxicity, Zhang, Z.; Hatta, H.; Tanabe, K.; Nishimoto, S. Pharm. Res. 2005, 22, 381–389.
  19. Modulated drug release from the stem-and-loop structured oligodeoxynucleotide upon UV-A irradiation in the presence of target DNA, Tanabe, K.; Nakata, H.; Mukai S.; Nishimoto, S. Org. Biomol. Chem. 2005, 3, 3893–3897.
  20. Aminopeptidase N/CD13 targeting fluorescent probes: Synthesis and application to tumor cell imaging, Zhang, Z.; Harada, H.; Tanabe, K.; Hatta, H.; Hiraoka, M.; Nishimoto, S. Peptides 2005, 26, 2182–2187.
  21. Electrochemical evaluation of alternating duplex–triplex conversion effect on the anthraquinone-photoinjected hole transport through DNA duplex immobilized on a gold electrode, Tanabe, K.; Iida, H.; Haruna, K.; Kamei, T.; Okamoto, A.; Nishimoto, S. J. Am. Chem. Soc. 2006, 128, 692–693.
  22. Synthesis and DNA cleavage reaction characteristics of enediyne prodrugs activated via an allylic rearrangement by base or UV irradiation, Tachi, Y.; Dai, W. –M.; Tanabe, K.; Nishimoto, S. Bioorg. Med. Chem. 2006, 14, 3199–3209.
  23. Effects of structural modification on the DNA binding properties and photo-induced cleavage reactivity of propargylic sulfones conjugated with an anthraquinone structure, Haruna, K.; Kanezaki, H.; Tanabe, K.; Dai, W. –M.; Nishimoto, S. Bioorg. Med. Chem. 2006, 14, 4427–4432.
  24. Photo-induced release of fluorescent probe in the presence of target DNA: synergetic effect of two types of oligonucleotides with indolequinone–coumarin conjugate and flavin photosensitizer, Tanabe, K.; Tachi, Y.; Okazaki, A.; Nishimoto, S. Chem. Lett. 2006, 35, 938–939.
  25. 2-Oxoalkyl caged oligonucleotides: one-electron reductive activation into emergence of ordinary hybridization property by hypoxic X-irradiation, Tanabe, K.; Kanezaki, H.; Ishii, H.; Nishimoto, S. Org. Biomol. Chem. 2007, 5, 1242–1246.
  26. One-electron photooxidation and site-selective strand cleavage at 5-methylcytosine in DNA by sensitization with 2-methyl-1,4-naphthoquinone-tethered oligonucleotides, Tanabe, K.; Yamada, H.; Nishimoto, S. J. Am. Chem. Soc. 2007, 129, 8034–8040.
  27. Current molecular design of intelligent drugs and imaging probes targeting tumor-specific microenvironment, Tanabe, K.; Zhang, Z.; Ito, T.; Hatta, H.; Nishimoto, S. Org. Biomol. Chem. 2007, 5, 3745–3757.
  28. Photocurrent response after enzymatic treatment of DNA duplexes immobilized on gold electrodes: electrochemical discrimination of 5-methylcytosine modification in DNA, Yamada, H.; Tanabe, K.; Nishimoto, S. Org. Biomol. Chem.2008, 6, 272–277.
  29. Fluorometric identification of 5-methylcytosine modification in DNA: combination of photosensitized oxidation and invasive cleavage, Yamada, H.; Tanabe, K.; Nishimoto, S. Bioconjugate Chem. 2008, 19, 20–23.
  30. Emission under hypoxia: one-electron reduction and fluorescence characteristics of an indolequinone-coumarin conjugate, Tanabe, K.; Hirata, N.; Harada, H.; Hiraoka, M.; Nishimoto, S. ChemBioChem. 2008, 9, 426–432.
  31. One-Electron reductive template-directed ligation of oligodeoxynucleotides possessing disulfide bond, Tanabe, K.; Kuraseko, E.; Yamamoto, Y.; Nishimoto, S. J. Am. Chem. Soc. 2008, 130, 6302–6303.
  32. Photoelectrochemical evaluation of pH effect on hole transport through triplex-forming DNA immobilized on a gold electrode, Haruna, K.; Iida, H.; Tanabe, K.; Nishimoto, S. Org. Biomol. Chem. 2008, 6, 1613–1617.
  33. The pH effect on the naphthoquinone-photosensitized oxidation of 5-methylcytosine, Yamada, H.; Tanabe, K.; Ito, T.; Nishimoto, S. Chem. Eur. J. 2008, 14, 10453–10461.
  34. Radiation- and photo-induced activation of 5-fluorouracil prodrugs as a strategy for the selective treatment of solid tumors, Ito, T.; Tanabe, K.; Yamada, H.; Hatta, H.; Nishimoto, S. Molecules 2008, 13, 2370–2384.
  35. Radiolytic one-electron reduction characteristics of tyrosine derivative caged by 2-oxopropyl group, Tanabe, K.; Ebihara, M.; Hirata, N.; Nishimoto, S. Bioorg. Med. Chem. Lett. 2008, 18, 6126–6129.
  36. Radiolytic activation of cytarabine prodrug possessing 2-oxoalkyl group: one-electron reduction and cytotoxicity characteristics, Hirata, N.; Fujisawa, Y.; Tanabe, K.; Harada, H.; Hiraoka, M.; Nishimoto, S. Org. Biomol. Chem. 2009, 7, 651–654. (Selected in Hot Articles)
  37. DNA Hairpins Containing a Diaminostilbene Derivative as a Photo-induced  Electron Donor for Probing the Effects of Single-Base Mismatches on Excess Electron Transfer in DNA, Ito, T.; Hayashi, A.; Kondo, A.; Uchida, T.; Tanabe, K.; Yamada, H.; Nishimoto, S. Org. Lett. 2009, 11, 927–930.
  38. Pathways of Excess Electron Transfer in Phenothiazine-tethered DNA Containing Single-base Mismatches, Ito, T.; Kondo, A.; Kamashita, T.; Tanabe, K.; Yamada, H.; Nishimoto, S. Org. Biomol. Chem. 2009, 7, 2077–2081.
  39. Preparation and Fluorescence Properties of Fluorophore-labeled Avidin-biotin System Immobilized on Fe3O4 Nanoparticles through Functional Indolequinone Linker, Hirata, N.; Tanabe, K.; Narita, A.; Tanaka, K.; Naka, K.; Chujo, Y.; Nishimoto, S. Bioorg. Med. Chem. 2009, 17, 3775–3781.
  40. Monitoring of biological one-electron reduction by 19F-NMR using hypoxia selective activation of a 19F-labeled indolequinone derivative, Tanabe, K.; Harada, H.; Narazaki, M.; Tanaka, K.; Inafuku, K.; Komatsu, H.; Ito, T.; Yamada, H.; Chujo, Y.; Matsuda, T.; Hiraoka, M.; Nishimoto, S. J. Am. Chem. Soc. 2009, 131, 15982–15983.
  41. Indolequinone-rhodol conjugate as a fluorescent probe for hypoxic cells: enzymatic activation and fluorescence properties, Komatsu, H.; Harada, H.; Tanabe, K.; Hiraoka, M.; Nishimoto, S. MedChemComm 2010, 1, 50–53.
  42. Radiolytic cyclization of stem-and-loop structured oligodeoxynucleotide with neighboring arrangement of α,ω-bis-disulfides, Tanabe, K.; Matsumoto, E.; Ito, T.; Nishimoto, S. Org. Biomol. Chem. 2010, 8, 4837–4842.
  43. Monitoring of duplex and triplex formation by 19F NMR using oligodeoxynucleotides possessing 5-fluorodeoxyuridine unit as 19F signal transmitter, Tanabe, K.; Sugiura, M.; Nishimoto, S. Bioorg. Med. Chem. 2010, 18, 6690–6694.
  44. Anthraquinone-Sensitized Photooxidation of 5-Methylcytosine in DNA Leading to Piperidine-Induced Efficient Strand Cleavage, Yamada, H.; Kitauchi, Y.; Tanabe, K.; Ito, T.; Nishimoto, S. Chem. Eur. J. 2011, 17, 2225–2235.
  45. 13C-labeled indolequinone-DTPA-Gd conjugate for NMR probing cytochrome:P450 reductase-mediated one-electron reduction, Komatsu, H.; Tanabe, K.; Nishimoto, S. Bioorg. Med. Chem. Lett. 2011, 21, 790–793.
  46. Photoinduced electron injection into DNA by N-cyclopropyl-1-aminonaphthalene, Ito, T.; Uchida, T.; Tanabe, K.; Yamada, H.; Nishimoto, S. J. Photochem. Photobiol. A: Chem. 2011, 219, 115–121.
  47. Preparation of Functionalized Oligodeoxynucleotides and Photochemical One-electron Oxidation of 5-Methylcytosine in DNA, Tanabe, K.; Yamada, H.; Nishimoto, S. J. Synth. Org. Chem., Jpn.,2011, 69, 814–822.
  48. αvβ3-Integrin-Targeting Lanthanide Complex: Synthesis and Evaluation as a Tumor-Homing Luminescent Probe, Ito, T.; Inoue, M.; Akamatsu, K.; Kusaka, E.; Tanabe, K.; Nishimoto, S. Bioorg. Med. Chem. Lett. 2011, 21, 3515–3518.
  49. Radiolytic Reduction Characteristics of Artificial Oligodeoxynucleotides Possessing 2-Oxoalkyl Group or Disulfide Bonds, Tanabe, K.; Ito, T.; Nishimoto, S. J. Nucleic Acids,2011, ID816207.
  50. Reversible modification of oligodeoxynucleotides: click reaction at phosphate group and alkali treatment, Tanabe, K.; Ando, Y.; Nishimoto, S. Tetrahedron Lett. 2011, 52, 7135–7137.
  51. Synthesis and photooxidation of oligodeoxynucleotides containing 5-dimethylaminocytosine that functions as an efficient hole-trapping site in the positive-charge transfer through DNA duplex, Yamada, H.; Kurata, M.; Tanabe, K.; Ito, T.; Nishimoto, S. Org. Biomol. Chem. 2012, 10, 2035–2043.
  52. Reductive activation of 5-fluorodeoxyuridine prodrug possessing azide methyl group by hypoxic X-irradiation, Tanabe, K.; Ishizaki, J.; Ando, Y.; Ito, T.; Nishimoto, S. Bioorg. Med. Chem. Lett. 2012, 22, 1682–1685.
  53. Transporting Excess Electrons along Potential Energy Gradients Provided by 2'-Deoxyuridine Derivatives in DNA, Ito, T.; Hamaguchi, Y.; Tanabe, K.; Yamada, H.; Nishimoto, S. Angew. Chem. Int. Ed. 2012, 51, 7558–7561.
  54. Synthesis and One-Electron Reduction Characteristics of Radiation-Activated Prodrugs Possessing Two 5-Fluorodeoxyuridine Units, Tanabe, K.; Sugiura, M.; Ito, T.; Nishimoto, S. Bioorg. Med. Chem. 2012, 20, 5164–5168.
  55. Radiolytic reduction characteristics of drug-encapsulating DNA aggregates possessing disulfide bond, Tanabe, K.; Asada, T.; Ito, T.; Nishimoto, S. Bioconjugate Chem. 2012, 23, 1909–1914.
  56. Aggregate formation and radiolytic degradation of amphiphilic DNA block copolymer possessing disulfide bond, Tanabe, K.; Asada, T.; Nishimoto, S. Bioorg. Med. Chem. Lett. 2012, 22, 7045–7047.
  57. Ruthenium complexes with hydrophobic ligands that are key factors for optical imaging of physiological hypoxia, Komatsu, H.; Yoshihara, K.; Yamada, H.; Kimura, Y.; Son, A.; Nishimoto, S.; Tanabe, K. Chem. Eur. J. 2013, 19, 1971–1977.
  58. Chemical ligation of oligodeoxynucleotides by X-irradiation and its application to regulation of G-quadruplex formation, Tanabe, K.; Mizoe, T.; Sugiura, M.; Okada, K.; Nishimoto, S. Bioorg. Med. Chem. Lett. 2013, 23, 2098–2100.
  59. Stepwise Regulation of Hole Transport in DNA by Control of Triplex Formation, Haruna, K.; Iida, H.; Nishimoto, S. Tanabe, K. Bioorg. Med. Chem. 2013, 21, 2682–2686.
  60. Site-Specific DNA oxidation by a Dinuclear Copper Complex Containing a Photoisomerizable Azobenzene Ligand, Ito, T.; Akamatsu, K.; Takeuchi, K.; Satani, M.; Tanabe, K.; Nishimoto, S. Inorg. Chim. Acta, 2013, 408, 230–234.
  61. Enzyme-Catalyzed Conversion of Chemical Structures on the Surface of Gold Nanorods, Kusaka, E.; Ito, T.; Tanabe, K.; Nishimoto, S. Bioconjugate Chem. 2013, 24, 1435–1444.
  62. Probing DNA mismatched and bulged structures by 19F NMR using oligodeoxynucleotides with 19F-labeled nucleobase, Tanabe, K.; Tsuda, T.; Ito, T.; Nishimoto, S. Chem. Eur. J. 2013, 19, 15133–15140.
  63. Electron Transport through 5-Substituted Pyrimidines in DNA: Electron Affinities of Uracil and Cytosine Derivatives Differently Affect the Apparent Efficiencies, Ito, T.; Kurihara, R.; Utsumi, N.; Hamaguchi, Y.; Tanabe, K.; Nishimoto, S. Chem. Comm. 2013, 49, 10281–10283.
  64. Oligonucleotides with consecutive alkylated phosphate units: Aggregation characteristics and drug transport into living cells, Tanabe, K.; Ando, Y.; Hara, D.; Ito, T.; Nishimoto, S. RSC advances 2014, 4, 13367–13370.
  65. Regulation of DNAzyme function by hypoxic irradiation that induces one-electron reduction of 2-oxoalkyl group on thymine base. Kanezaki, H.; Nishimoto, S.; Tanabe, K. Rapid Communication in Photoscience 2014, 3, 79-80.
  66. Phosphorescent Ruthenium Complexes with Nitroimidazole Unit that Image Oxygen Fluctuation in Tumor Tissue, Son, A.; Kawasaki, A.; Hara, D.; Ito, T.; Tanabe, K. Chem. Eur. J. 2015, 21, 2527–2536.
  67. Hypoxic X-irradiation as an external stimulus for conformational change of oligodeoxynucleotides that possess disulfide bond and regulation of DNAzyme function. Tanabe, K.; Okada, K.; Sugiura, M.; Ito, T.; Nishimoto, S. Bioorg. Med. Chem. Lett. 2015, 25, 310–312.
  68. Controlling localization and excretion of nanoparticles by click modification of the surface chemical structures inside living cells. Ito, T.; Nakamura, T.; Kusaka, E.; Kurihara, R.; Tanabe, K. ChemPlusChem 2015, 80, 796–799.
  69. Water-soluble phosphorescent ruthenium complex with a fluorescent coumarin unit for ratiometric sensing of oxygen levels in living cells. Hara, D.; Komatsu, H.; Son, A.; Nishimoto, S.; Tanabe, K. Bioconjugate Chem. 2015, 26, 645–649.
  70. Confined Singlet Oxygen in Mesoporous Silica Nanoparticles: Selective Photochemical Oxidation of Small Molecules in Living Cells. Nakamura, T.; Son, A.; Umehara, Y.; Ito, T.; Kurihara, R.; Ikemura, Y.; Tanabe, K. Bioconjugate Chem. 2016, 27, 1058-1066.
  71. Preparation of alkyne-labeled 2-nitroimidazoles for identification of tumor hypoxia by Raman spectroscopy. Kurihara, R.; Ikemura, Y.; Tanabe, K. Bioorg. Med. Chem. Lett. 2016, 26, 4892-4894.
  72. Dioxetane formation and chemiluminescent emission upon the combination of a vinylphenol derivative with naphthalene endoperoxide. Umehara, Y.;Son, A.; Kondo, T.; Tanabe, K. RSC advances 2017, 7, 9472-9475.
  73. Aggregate Formation of Oligonucleotides that Assist Molecular Imaging for Tracking of the Oxygen Status in Tumor Tissue. Yoshihara, K.; Takagi, K.; Son, A.; Kurihara, R.; Tanabe, K. ChemBioChem 2017, 18, 1650-1658.
  74. Tracking the oxygen status in the cell nucleus by using a Hoechst tagged phosphorescent ruthenium complex, Hara, D.; Umehara, Y.; Son, A.; Asahi, W.; Misu, S.; Kurihara, R.; Kondo, T.; Tanabe, K. ChemBioChem 2018, 18, 956-962.
  75. Phosphorescent Ruthenium Complexes with Bromopyrene Unit that Enhance oxygen sensitivity, Kurihara, R.; Ikegami, R.; Asahi, W.; Tanabe, K. Bioorg. Med. Chem. 2018, 26, 4595-4601.
  76. Release of small molecules from aggregates consisting of an amphiphilic oligonucleotide functionalized by a photochromic azobenzene unit, Itagaki, T.; Kurihara, R.; Tanabe, K. Tetrahedron Lett. 2018, 59, 3112-3115.
  77. Confinement of singlet oxygen generated from ruthenium complex-based oxygen sensor in the pores of mesoporous silica nanoparticles, Kitajima, N.; Umehara, Y.; Son, A.; Kondo, T.; Tanabe, K. Bioconjugate Chem. 2018, 29, 4168-4175.
  78. Glutathione arrest in the pores of mesoporous silica nanoparticles bearing maleimide units to enhance the radiation effects, Ito, M.; Kurihara, R.; Tanabe, K. Photomed. Photobiol. 2019, in press.
  79. Easy access to water-soluble cationic porphyrin-β-carboline conjugates as potent photocytotoxic and DNA cleaving agents. Reddy, P. O. V.; Shekar, K. P. C.; Khandagale, S. B.; Hara, D.; Son, A.; Ito, T.; Tanabe, K. Kumar, D. Asian J. Org. Chem. 2019, 8, 269-274.
  80. Enzymatic activation of indolequinone-substituted 5-fluorodeoxyuridine prodrugs in hypoxic cells, Jiho, Y.; Kurihara, R.; Kawai, K.; Yamada, H.; Uto, Y.; Tanabe, K. Bioorg. Med. Chem. 2019, 29, 1304-1307.
  81. Biological reduction of nitroimidazole-functionalized gold nanorods for photoacoustic imaging of tumor hypoxia, Umehara, Y.; Kageyama, T.; Son, A.; Kondo, T.; Tanabe, K. RSC Advances 2019, 9, 16863-16868. 　　　　　
  82. Aggregate formation of BODIPY-tethered oligonucleotides that led to efficient intracellular penetration and gene regulation, Asahi, W.; Kurihara, R.; Takeyama, K.; Umehara, Y.; Kimura, Y.; Kondo, T.; Tanabe, K. ACS Appl. Bio Mater. 2019, 2, 4456-4463.
  83. Chemical approaches for the design of hypoxia-targeting molecular probes and drugs. Tanabe, K. Radiation Biology Research Communications 2019, 54, 251-265.
  84. Hybridization of oligonucleotides with hydrophobic peptide nucleic acids assists their cellular uptake via aggregate formation. Misu, S.; Kurihara, R.; Kainuma, R.; Sato, R.; Nishihara, T. Tanabe, K. ChemBioChem 2020, 21, 1140-1143.
  85. Cellular uptake of aggregates consisting of oligodeoxynucleotides bearing alkyl chain at strand end, Kitao, A.; Kurihara, R.; Tanabe, K. Photomed. Photobiol. 2020, in press.
  86. Modulation of cell membrane functionalization by aggregates of oligodeoxynucleotides containing alkyl chain-modified uridines, Kainuma, R.; Motohashi, Y.; Nishihara, T.; Kurihara, R.; Tanabe, K. Org. Biomol. Chem. 2020, 18, 5406-5413.
  87. Monitoring intracellular metal ion complexation with acetylene-tagged ligand by Raman spectroscopy, Takemura, S.; Watanabe, H.; Nishihara, T.; Okamoto, A.; Tanabe, K. RSC Advances 2020, 10, 36119-36123.
  88. Excited states of thio-2'-deoxyuridine bearing an extended conjugated system: 3,5-Diacetyl-5-phenylethynyl-4-thio-2'-deoxyuridine, Nonoshita, D.; Kashihara, W.; Tanabe, K.; Isozaki, T.; Xu, Y.; Suzuki, T. J. Phys. Chem. A 2021, 125, 597-606.
  89. Phosphonated mesoporous silica nanoparticles bearing ruthenium complexes as molecular probes for tracking oxygen levels in cells and tissues, Umehara, Y.; Kimura, Y.; Kleitz, F.; Nishihara, T.; Kondo, T.; Tanabe, K. RSC Advances 2021, 11, 5865-5873.
  90. Raman spectra of acetylene-tagged anthraquinone derivatives in various solutions, Makanai, H.; Nishihara, T.; Tanabe, K. Photomed. Photobiol. 2021, 42, 17-19.
  91. Changes of CC triple bond vibration that disclosed non-canonical cytosine protonation in i-motif-forming oligodeoxynucleotides, Itaya, R.; Idei, W.; Nakamura, T.; Nishihara, T.; Kurihara, R.; Okamoto, A.; Tanabe, K. ACS Omega 2021, 6, 31595-31604.
  92. pH-responsive aggregate consisted of oligodeoxynucleotides bearing nitrophenol group that deliver drugs into acidic cells, Yokota, S.; Motohashi, Y.; Nishihara, T.; Tanabe, K. Bioorg. Med. Chem. Lett.2022, 58, 128519.
  93. Surface-Enhanced Raman Scattering Identification of Nucleic Acid Targets by Acetylene-Tagged Hoechst Molecule Binding with DNA-Tethered Gold Nanoparticles, Makanai, H.; Nishihara, T.; Tanabe, K. ACS Appl. Nano Mater. 2022, 5, 2935–2942.
  94. Hypoxic X-irradiation as a trigger for reduction of metal ion and azide-alkyne cycloaddition on oligodeoxynucleotides, Akisawa,K; Makanai, H.; Nishihara, T.; Tanabe, K. Tetrahedron Lett. 2022, 92, 153658.
  95. Preparation of a multifunctional photoactivated prodrug on a streptavidin scaffold bearing a DNA aptamer, Motohashi,Y; Nishihara, T.; Tanabe, K. Bioorg. Med. Chem. Lett. 2022, 71, 128819.
  96. The pH-dependent Raman signal enhancement of alkyne-tagged Hoechst molecule that binds with oligodeoxynucleotides on gold nanoparticles, Makanai, H.; Nishihara, T.; Tanabe, K. Chem. Lett. 2022, 51, 1135–1138.
  97. Copper ion trapping by artificial oligonucleotides identified using Raman spectroscopy, Meisho, K.; Nishihara, T.; Tanabe, K. Photomed. Photobiol. 2022, in press.
  98. Raman signal enhancement by DABCYL-substitution on DNA aptamer for identification of cellular ATP, Watanabe, H.; Maehara, D.; Nishihara, T.; Tanabe, K. Bioconjugate Chem. 2022, 33, 2314–2319.
  99. Synthesis of azafluoranthenes by iridium-catalyzed [2+2+2]cycloaddition and evaluation of their fluorescent properties, Sawano, T.; Takamura, K.; Yoshikawa, T.; Murata, K.; Koga, M.; Yamada, R.; Saito, T.; Tabata, K.; Ishii, Y.; Kashihara, W.; Nishihara, T.; Tanabe, K.; Suzuki, T.; Takeuchi, R. Org. Biomol. Chem. 2023, 21, 323–331.
  100. Synthesis of red-light-responsive pheophorbide-a tryptamine conjugate photosensitizer for lysosome localization photodynamic therapy, Pandurang, T. P.; Kumar, K.; Verma, N.; Yamada, R.; Nishihara, T.; Tanabe, K.; Dalip, K. ChemMedChem. 2023, 18, e2022004.
  101. Alkyne-tethered oligodeoxynucleotides that allow simultaneous detection of multiple DNA/RNA targets using Raman spectroscopy, Watanabe, H.; Maehara, D.; Nishihara, T.; Tanabe, K. RSC Adv. 2023, 13, 20756–20760.
  102. Encoding thiol metabolite information into a DNA sequence by disulfide exchange reaction on oligodeoxynucleotides for parallel analysis of the metabolite and mRNA, Motohashi, Y.; Moritani, S.; Nishihara, T.; Tanabe, K. ChemistrySelect 2023, 8, e202302662.
  103. DNA Encoding Strategy for the Identification and Quantification of Poorly Reactive Target Metabolite Using Phenylboronic acid-tethered Oligodeoxynucleotides, Motohashi, Y.; Nishihara, T.; Tanabe, K. Chem. Lett. 2023, 52, 732–735.
  104. Hoechst-modification on oligodeoxynucleotides for efficient transport to the cell nucleus and gene regulation, Makanai, H.; Nishihara, T.; Nishikawa, M.; Tanabe, K. ChemBioChem 2023, in press.
  105. Excited state properties of 5-fluoro4-thiothymidine derivative, Sato, R.; Yamada, Y.; Kashihara, W.; Nishihara, T.; Tanabe, K.; Xu, Y. -Z.; Suzuki, T. Photochem. Photobiol. 2024, in press.
  106. A Detection System Using Sensing Motiftethered Oligodeoxynucleotides for Multiplex Biomolecular Analysis, Nishihara, T.; Motohashi, Y.; Mio, R.; Sugawara, M. Tanabe, K. Chem. Commun. 2024, in press.
  107. Tracking and recording of intracellular oxygen concentration changes in cell organelles: Preparation and function of azide-modified fluorescent probes, Makanai, H.; Kanda, M.; Harada, S.; Nishihara,T.; Tanabe, K. RSC Adv.2024, in press.
  108. Hoechst modification by strain-promoted azide-alkyne cycloaddition for transport of functional molecules into the cell nucleus, Makanai, H.; Mochizuki, D.; Nishihara,T.; Tanabe, K. Bioorg.Med. Chem. Lett. 2024, in press.

著書・解説記事

  1. 新しい抗低酸素細胞薬の分子設計
    西本清一、張周恩、田邉一仁、伊藤健雄、八田博司
    癌の臨床 (Japanese Journal of Cancer Clinics)　vol.52, No.1, 2006, p1–9
  2. DNA二重鎖形成を自在に操る金属イオン
    田邉一仁
    月刊化学　平成18年5月号　p59–60　2006年の化学　注目の論文
  3. 光照射によって機能発現する人工核酸：DNA中メチル化シトシンの検出法と遺伝子配列認識機能をもつプロドラッグの開発
    田邉一仁
    日本化学会生体機能関連化学部会News Letter Vol.21, No. 3, p16–20　(2006.11.30発刊)
  4. 光照射や放射線照射により機能を発現するプロドラッグ（第18章）
    田邉一仁
    化学フロンティア　ゲノム化学－医学、分子生物学への応用と展開　齋藤烈・杉山弘・中谷和彦編　(2007.3.31発刊)
  5. がん低酸素領域で機能するターゲティング分子・イメージング分子（I-5）
    田邉一仁　伊藤健雄　西本清一
    蛋白質・核酸・酵素　増刊号　「ケミカルバイオロジー」　p1588–1593 長野哲雄・長田裕之・菊地和也・上杉志成編　(2007.10.10発刊)
  6. Rhodol骨格に基づく新規低酸素環境認識プローブの開発とバイオイメージングへの応用
    小松広和　原田浩　山田久嗣　伊藤健雄　田邉一仁　西本清一
    日本分析化学会第58年会　展望とトピックス　p14 (2009.9.10発行)
  7. がん低酸素細胞を標的とするプロドラッグ・分子プローブ
    田邉一仁
    化学と工業　2010年8月号　飛翔する若手研究者　p651
  8. 一塩基多型検出法のインベーダー法
    田邉一仁
    有機合成化学協会誌　2011年7月号　十字路欄　p825
  9. 細胞内還元反応を活用した低酸素環境イメージング
    田邉一仁　原田浩　平岡眞寛　西本清一
    実験医学2012年増刊号（疾患克服を目指した最新ケミカルバイオロジー）　浦野泰照編　p89–95
  10. 分子プローブで低酸素環境を可視化する
    田邉一仁
    月刊「化学」解説記事　2014年　2月号　p12
  11. 生体内低酸素を可視化する機能性ナノ粒子の分子設計
    田邉一仁・近藤輝幸
    化学工業　2021年　4月号　p213
  12. 化学修飾とラマン分光法を用いた核酸構造解析
    田邉一仁
    Jasco report　2023, vol. 65, No.1, p6-11